human oscc cell line cal27 (ATCC)
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human oscc cell line cal27
Human Oscc Cell Line Cal27, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 1949 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+oscc+cell+lines+cal27/CAL+27/pm42265343-60-3-9
Average 98 stars, based on 1949 article reviews
Human Oscc Cell Line Cal27, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 1949 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+oscc+cell+lines+cal27/CAL+27/pm42265343-60-3-9
Average 98 stars, based on 1949 article reviews
human oscc cell line cal27 - by Bioz Stars,
2026-09
98/100 stars
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Expressing:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). High Throughput Screening Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). RNA sequencing:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Comparison:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Quantitative RT-PCR:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Immunohistochemistry:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Blocking Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). In Vitro:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Over Expression:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Knockdown:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). CCK-8 Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Transwell Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Wound Healing Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Negative Control:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Staining:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Western Blot:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Transfection:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Plasmid Preparation:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Cell Counting:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Flow Cytometry:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Activation Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Immunoprecipitation:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Binding Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Phospho-proteomics:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). MTS Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Soft Agar Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Colony Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Ubiquitin Proteomics:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Incubation:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). shRNA:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Co-Immunoprecipitation Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Caspase-3 Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Activity Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Isolation:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). In Vivo:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). Derivative Assay:Article Title: Liposomal Salvianolic Acid B Enhances ALA-PDT in Oral Leucoplakia via ROS and AKT/mTOR Signalling. Article Snippet: Samples were negatively stained with 2% uranyl acetate and imaged using a FEI Tecnai F20 transmission electron microscope. Article Title: Dual-targeted NIR-II AIE theranostic nanoparticles disrupt HNRNPC-driven ITGA1 + myCAFs differentiation and immune evasion in oral squamous cell carcinoma. Article Snippet: Oral squamous cell carcinoma (OSCC) remains a therapeutic challenge due to its aggressive metabolism-driven progression and immunosuppressive tumor microenvironment (TME).. Through proteomic and transcriptomic analyses, we identified HNRNPC as a novel driver of OSCC progression via aberrant glycolysis and TGFβ-mediated differentiation of ITGA1 myofibroblastic cancer-associated fibroblasts (myCAFs), which directly induce CD8 T cell exhaustion.. Given the lack of strategies that simultaneously target both tumor and stromal compartments, we engineered a theranostic solution: Near-infrared-II (NIR-II) imaging-guided aggregationinduced emission nanoparticles (AIE NPs) dually conjugated with antibodies against HNRNPC and ITGA1 (NPsH-I). |
